Endocrine Abstracts

Genetic variants causing adrenal insufficiency (AI) are either disrupting corticosteroid production exclusively leading to isolated AI or they are causing additional organ malfunctions as part of a syndromic form of AI. In isolated AI, genetic disorders may affect structure and function of the adrenal cortex or adrenal steroidogenesis specifically, but often also lead to overall disturbances of steroidogenesis affecting other steroid organs (mainly the gonads ...

The human adrenal cortex consists of three layers in which specific steroid hormones are produced. Human adrenal NCI-H295A (A) and NCI-H295R (R) cells, originate from the same adrenocortical tumor and express all genes essential for steroidogenesis. Therefore they often serve as a suitable model to study human steroidogenesis. No data are available comparing steroidogenesis of A vs. R cells. Assuming no difference, research data from these two cell lines are directly compared....